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Related Experiment Videos

Synovial sarcoma with massive ossification--a case report.

Seigo Hara1, Masahito Hatori, Masami Hosaka

  • 1Department of orthopaedic surgery, Tohoku Rosai Hospital, Sendai, Japan.

Upsala Journal of Medical Sciences
|December 3, 2003
PubMed
Summary

This case study highlights a rare synovial sarcoma with extensive ossification. Despite recurrence, the patient showed a favorable prognosis, suggesting ossified synovial sarcomas may be less aggressive.

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Area of Science:

  • Orthopedic Oncology
  • Pathology
  • Molecular Diagnostics

Background:

  • Synovial sarcoma, a rare soft tissue malignancy, typically arises in extremities.
  • Extensive osteoid production within synovial sarcoma is an uncommon presentation.
  • Accurate diagnosis and prognostic indicators are crucial for patient management.

Observation:

  • An 81-year-old female presented with a recurrent, painful soft tissue mass in the right knee.
  • Imaging revealed a 5 cm mass with significant ossification.
  • Microscopic examination showed spindle cells with prominent ossification, lacking epithelial components.

Findings:

  • The diagnosis was confirmed via reverse-transcription polymerase chain reaction (RT-PCR), identifying the SYT-SSX1 fusion gene transcript.

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  • Immunohistochemistry revealed vimentin positivity and focal cytokeratin positivity.
  • The excised tumor exhibited a trabecular ossification pattern.

    • Implications:

    • This case suggests that synovial sarcomas with extensive ossification may have a better prognosis.
    • Long-term survival without metastasis, despite recurrent disease, supports this observation.
    • Further research into the prognostic significance of ossification in synovial sarcoma is warranted.