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Related Experiment Videos

Gender differences in bone turnover in 2-year-old Thoroughbreds.

B F Jackson1, C Lonnell, K Verheyen

  • 1Department of Veterinary Basic Sciences, The Royal Veterinary College, London NW1 0TU.

Equine Veterinary Journal
|December 3, 2003
PubMed
Summary

Gender influences bone turnover in young racehorses, with colts showing higher bone formation and resorption markers than fillies. These differences may impact training adaptation and injury risk.

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Area of Science:

  • Equine sports medicine
  • Bone biology
  • Biochemistry

Background:

  • Skeletal injuries are a significant cause of morbidity and mortality in racehorses.
  • Age, gender, and season are known risk factors for equine skeletal injuries.

Purpose of the Study:

  • To investigate whether cellular processes in bone contribute to the known effects of age, gender, and season on racehorse injury risk.
  • To utilize biochemical markers of bone cell activity to assess bone turnover in young Thoroughbreds.

Main Methods:

  • Monthly blood samples were collected from 2-year-old Thoroughbreds in race training over a 10-month period.
  • Concentrations of osteocalcin (OC, bone formation), carboxyterminal cross-linked telopeptide of type I collagen (ICTP, bone resorption), and carboxyterminal propeptide of type I collagen (PICP) were measured.

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  • Study included 84 colts and 63 fillies, with a mean age of 20 months at the study's commencement.

    • Main Results:

    • Colts exhibited significantly higher mean concentrations of OC and ICTP compared to fillies.
    • No statistically significant gender effect was observed for PICP, except for a higher concentration in fillies during May.
    • Neither age nor season demonstrated a significant effect on the measured bone marker concentrations within the study's parameters.

    Conclusions:

    • Significant gender differences in bone turnover markers (OC and ICTP) were identified in 2-year-old Thoroughbreds.
    • These gender-based variations in bone cell activity may influence how horses adapt to training and their susceptibility to skeletal injury.
    • Observed differences in marker concentrations may relate to bone size, skeletal maturation rates, and potential influence of sex hormones on collagen turnover in fillies.