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Cardiac near-field morphology during conduction around a microscopic obstacle--a computer simulation study.

G Plank1, E Vigmond, L J Leon

  • 1Institut für Medizinische Physik und Biophysik, Karl Franzens Universität Graz, Graz, Austria. gernot.plank@uni-graz.at

Annals of Biomedical Engineering
|December 3, 2003
PubMed
Summary

Conduction obstacles in cardiac tissue distort the electric near-field (E) vector loop. Despite distortions, the peak of the E loop reliably indicates the direction of cardiac electrical propagation.

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Area of Science:

  • Biophysics
  • Cardiac Electrophysiology

Background:

  • The cardiac electric near-field (E) exhibits a vector loop during depolarization.
  • Observed experimental E loop morphologies deviate from theoretical predictions for continuous conduction.

Purpose of the Study:

  • To investigate the influence of microscopic conduction obstacles on E vector loop morphology.
  • To determine if the peak of distorted E loops remains a reliable indicator of propagation direction.

Main Methods:

  • Utilized a computer model of cardiac tissue with a central conduction obstacle.
  • Simulated the behavior of the electric near-field (E) in an unbounded volume conductor.
  • Analyzed E vector loop morphologies and compared propagation directions (phiI(m)) with E field directions (phiE).

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Main Results:

  • Simulated E loop distortions closely matched experimentally observed morphologies.
  • Differences between intracellular propagation direction (phiI(m)) and E field direction (phiE) were minimal (<18 degrees).
  • Obstacles caused significant loop deformations, especially during initial and terminal phases of depolarization.

Conclusions:

  • Microscopic conduction obstacles contribute to the variety of experimentally observed E vector loop morphologies.
  • The electric near-field (E) remains a reliable indicator of the intracellularly determined direction of cardiac electrical propagation (phiI(m)).