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Related Experiment Videos

Can nasal continuous positive airway pressure decrease clinic blood pressure in patients with obstructive sleep

Ye Tun1, Wataru Hida, Shinichi Okabe

  • 1First Department of Internal Medicine, Tohoku University School of Medicine, Sendai 980-8574, Japan.

The Tohoku Journal of Experimental Medicine
|December 3, 2003
PubMed
Summary

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Continuous positive airway pressure (CPAP) therapy significantly lowers blood pressure in hypertensive patients with obstructive sleep apnea (OSA). This treatment may reduce cardiovascular risks associated with OSA.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Pulmonology

Background:

  • Obstructive sleep apnea (OSA) is linked to systemic hypertension.
  • OSA is an independent risk factor for daytime hypertension.
  • Understanding CPAP's effect on blood pressure in OSA patients is crucial.

Purpose of the Study:

  • To investigate the short- and long-term effects of nasal CPAP.
  • To assess CPAP's impact on hypertensive and normotensive OSA patients.

Main Methods:

  • Forty-six patients with moderate to severe OSA were enrolled.
  • Nasal CPAP treatment was administered.
  • Clinic blood pressure, heart rate, and body weight were monitored for one year.

Main Results:

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  • 54.3% of OSA patients had hypertension.
  • Hypertensive OSA patients showed significant blood pressure reduction with CPAP.
  • Normotensive OSA patients had no significant blood pressure changes.
  • CPAP lowered blood pressure in untreated hypertensive OSA patients similar to those on medication.
  • No significant changes in heart rate or correlation between weight loss and blood pressure reduction were observed.

Conclusions:

  • Nasal CPAP monotherapy can substantially lower blood pressure in hypertensive OSA patients.
  • CPAP treatment may reduce cardiovascular morbidity and mortality in OSA.
  • Further research into CPAP's role in managing hypertension in OSA is warranted.