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[Effect of nitric oxide in vestibular compensation]
Zi-dong Jiang1, Lian-shan Zhang
1Department of Otolaryngology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. zidongjiangcn@yahoo.com.cn
Objective:
To study the effect of nitric oxide (NO) in vestibular compensation after unilateral vestibular deafferentation.
Methods:
Eighteen animals were divided into two groups, 6 of group a as control, 12 of group b received gentamicin intratympanic injection in the left ear. Half of the animals were killed respectively after 5 days and 10 days. Vestibular endorgan and brainstem tissue sections were subjected to NADPH-d reactive test of NOS for histochemical examination.
Results:
In group a, NOS-like reactivity in both sides of vestibular endorgan and nucli. In group b during 5 days, NOS-like reactivity in right side of vestibular endorgan and nucli, those of the left side were negative. During 10 days, NOS-like reactivity only in the right side of vestibular endorgan.
Conclusions:
Changes of NOS expression in the contralateral vestibular nucli might have played a role in vestibular compensation.