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Updated: Aug 11, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
Published on: October 15, 2010
[Endothelium derived relaxing factor and its effect on vascular disease]
1College of Food and Bioengineering, South China University of Technology, Guangzhou 510640, China.
Abstract:
The finding of endothelium derived relaxing factor (EDRF) and the illumination of its chemical identity, bio-synthesis and physiological functions promoted greatly the research on vascular disease. The EDRF was verified as NO or R-O-NO by many experimental results, and several pathological processes such as hypertension, atherosclerosis and heart failure were considered to be associated with abnormalities of endothellium-dependent vascular relaxation and decrease of basal EDRF and/or storage EDRF. As the provider of EDRF, Nitryl vascular relaxation substance could remedy EDRF and might play an important role in clinical therapy and prevention of human vascular disease.
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