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Functional and molecular characterization of neuronal nicotinic ACh receptors in rat hippocampal interneurons

Jerrel L Yakel1, Zuoyi Shao

  • 1Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, F2-08, 111 T.W. Alexander Drive, P.O. Box 12233, Research Triangle Park, NC 27709, USA. yakel@niehs.nih.gov

Progress in Brain Research
|December 4, 2003
PubMed
Abstract

No abstract available in PubMed .

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Cholinergic Receptors: Nicotinic01:15

Cholinergic Receptors: Nicotinic

Nicotinic receptors are ligand-gated ion channels that are activated by acetylcholine and nicotine. Upon activation, they cause a rapid increase in the permeability of cells to K+, Na+, and Ca2+, followed by depolarization and excitation. They are in the autonomic ganglia, skeletal neuromuscular junction, CNS, and adrenal medulla.
There are two types of nicotinic receptors: neuromuscular (NM/NM/N1) and neuronal (NN/NN/N2). The two families differ based on their location and selectivity to...