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Published on: September 8, 2011
[Characteristic changes of acetylcholine receptor in rat lateral pterygoid muscles after functional mandibule
1Department of Orthodontics, Oral Hospital of Guangdong Province, Guangzhou 510280, China.
Objective:
The purpose of this study was to evaluate the maximum binding(Bmax) and affinity(Kd value) changes of acetylcholine receptor (n-AchR) in rat lateral pterygoid muscles after functional mandibule advancement.
Methods:
40 five-weeks-old male Sprague-Dawley rats were equally divided into experimental and control group. The mimic functional appliances were used in experiment group and the rats were killed after 1, 3, 7, 14 days. Radio-ligand binding assay (RBA) was applied to determine the maximum binding(Bmax) and Kd value of n-AchR of lateral pterygoid muscle.
Results:
The Bmax of n-AchR in experimental group was higher than that in control group and the Kd value always kept in high level.
Conclusion:
The functional orthopedics can increase the Bmax of n-AchR in rapid growing rat lateral pterygoid muscles.
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