Related Experiment Video
Updated: Jun 27, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
The Lupus Foundation as an additional source for case ascertainment: developing a community-based lupus registry.
S G Fitzgerald1, C K Kwoh, D McCarty
1Department of Rehabilitation Science and Technology, School of Health Rehabilitation and Science, University of Pittsburgh, Pennsylvania, USA.
Summary
The Lupus Foundation of America (LFA) chapter offered minimal benefit in identifying new systemic lupus erythematosus (SLE) cases for an established registry. Most potential cases were already documented, yielding few additional SLE diagnoses.
Area of Science:
- Rheumatology
- Epidemiology
- Public Health
Background:
- Population-based registries are crucial for understanding lupus epidemiology.
- Identifying incident cases of Systemic Lupus Erythematosus (SLE) can be challenging.
- Community organizations like the Lupus Foundation of America (LFA) may offer alternative case-finding strategies.
Purpose of the Study:
- To assess the utility of a local Lupus Foundation of America chapter as a supplementary source for identifying new SLE cases.
- To evaluate the overlap between cases identified through the LFA and an existing population-based incidence registry.
Main Methods:
- Membership and telephone records from the LFA Western Pennsylvania Chapter (WPC) were reviewed to identify potential lupus cases.
- Potential cases were cross-referenced with an established SLE incidence registry.
- Unmatched individuals were interviewed to confirm lupus diagnosis and gather demographic data.
Main Results:
- Out of 449 potential cases from the LFA-WPC, 108 (24%) were already registered.
- Of the remaining cases, 26 reported a lupus diagnosis in Allegheny County (1985-1990).
- Only 5 of these unmatched cases met criteria for definite or probable lupus.
Conclusions:
- The LFA-WPC provided a negligible advantage in identifying additional incident SLE cases beyond the established registry.
- Relying solely on the LFA chapter is not an efficient method for augmenting lupus case ascertainment in this population.
Related Concept Videos
02:20Longitudinal Research
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
01:15Secondary Lymphoid Organs
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
01:29Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
01:26Principles of Disease Surveillance
Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
01:23Investigation of Disease Outbreaks
Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...