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06:27
Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
Published on: May 6, 2013
Enteroviruses and type 1 diabetes mellitus
Harry W Haverkos1, Narayana Battula, D Peter Drotman
1Center for Drug Evaluation and Research, Food and Drug Administration, HFD-530, 5600 Fishers Lane, Rockville, MD 20857, USA. haverkosh@cder.fda.gov
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 4, 2003
Summary
The cause of type 1 diabetes mellitus (DM) remains unknown, but research suggests a complex interplay of genetic and environmental factors, including enteroviruses, may be involved in its development.
Area of Science:
- Immunology
- Virology
- Endocrinology
Background:
- Type 1 diabetes mellitus (DM) etiology is largely unknown despite extensive research.
- Identified risk factors include viral infections, genetics, nutrition, and chemical exposures.
- Current hypotheses suggest a multifactorial origin involving gene-environment interactions.
Purpose of the Study:
- To review epidemiologic data associating enteroviruses with type 1 DM.
- To explore potential pathogenic mechanisms linking enteroviruses to type 1 DM.
Main Methods:
- Literature review of epidemiologic studies.
- Analysis of proposed enteroviral pathogenesis mechanisms.
Main Results:
- Epidemiologic evidence suggests a link between enterovirus infections and type 1 DM.
- Potential mechanisms include direct viral damage, molecular mimicry, and autoimmune responses.
Conclusions:
- Enteroviruses are a potential environmental trigger for type 1 DM.
- Further research is needed to elucidate the precise role of enteroviruses in type 1 DM pathogenesis.
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