[Effect of erythrocytic G2-chalone on the erythrokinetics in mice]

It was shown that erythrocytic inhibitor (G2-cheilon) acted both on the proliferating and on differentiated cells of the erythroid series of the mouse bone marrow. The effect of cheilon was expressbd as soon as 3 hours after its administration and lasted for from 8 to 48 hours, depending on the extent of cell differentiation. In case of a single cheilon administration, despite significant erythropoiesis disturbances, erythrocyte count determined 8 to 12 days later persists within the control level. Repeated administration of cheilon was accompanied by a fall of the erythrocyte count at later periods of the experiment.