Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth factors.

F Aloisi1

  • 1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, I-00161, Rome, Italy.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|December 4, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vitro studies on the interactions between antigen-specific T line cells and CNS glial cells.

Cytotechnology·2012
Same author

Epstein-Barr virus and multiple sclerosis: interaction with HLA.

Genes and immunity·2011
Same author

Epstein-Barr virus nuclear antigen-1 B-cell epitopes in multiple sclerosis twins.

Multiple sclerosis (Houndmills, Basingstoke, England)·2011
Same author

Peripheral tissue release of interleukin-6 in patients with chronic kidney diseases: effects of end-stage renal disease and microinflammatory state.

Kidney international·2006
Same author

ATP regulates oligodendrocyte progenitor migration, proliferation, and differentiation: involvement of metabotropic P2 receptors.

Brain research. Brain research reviews·2005
Same author

Metabotropic P2 receptor activation regulates oligodendrocyte progenitor migration and development.

Glia·2005
Same journal

Primary Sjogren syndrome with suspected central nervous system inflammatory involvement.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Efficacy of repetitive transcranial magnetic stimulation for post-stroke spasticity: a meta-analysis of randomized controlled trials.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Diverging trends in motor neuron disease burden in China: an ageing-driven increase despite declining age-standardised rates - a GBD 2021 analysis.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Efficacy and safety of extended-interval dosing of natalizumab in multiple sclerosis: a systematic review and meta-analysis with subgroup evaluation.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Ultrashort echo time magnetic resonance angiography for embolized intracranial aneurysm with coil protrusion into the small parent vessel in the posterior circulation.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same journal

Mixing apples and antibodies: when the Cochrane average obscures the evidence in Alzheimer's disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
See all related articles

Growth factors are key to myelin repair in the central nervous system. Understanding their mechanisms may lead to treatments for demyelinating diseases like multiple sclerosis.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Myelination is crucial for central nervous system function.
  • Demyelinating diseases, such as multiple sclerosis, involve damage to myelin.
  • Repairing myelin (remyelination) is a therapeutic goal.

Purpose of the Study:

  • To explore the role of growth factors in myelination.
  • To understand the molecular mechanisms of oligodendrocyte function.
  • To identify strategies for promoting remyelination in neurological disorders.

Main Methods:

  • Reviewing recent studies on growth factor signaling pathways.
  • Analyzing the effects of growth factors on oligodendrocyte survival, proliferation, and differentiation.
  • Investigating experimental animal models of central nervous system injury.

Related Experiment Videos

Main Results:

  • Growth factors from various families influence oligodendrocyte behavior.
  • Manipulation of growth factors aids in understanding central nervous system repair mechanisms.
  • New insights into the identity and actions of key growth factors have emerged.

Conclusions:

  • Growth factors are critical regulators of myelination and remyelination.
  • Targeting growth factor pathways offers potential therapeutic strategies.
  • Further research aims to translate these findings to treat demyelinating diseases.