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[Expression of PTEN and p27 proteins in non-Hodgkin's lymphoma]
Yue-nan Li1, De-yun Feng, Hui Zheng
1Department of Pathology, Xiangya School of Medicine, Central South University, Changsha 410078, China.
Objective:
To investigate the effect of the expression of phosphatase and tensin homolog deleted on chromosome ten (PTEN) and p27 proteins in non-Hodgkin's lymphoma (NHL).
Methods:
The expressions of PTEN and p27 proteins were detected with immunohistochemical technique in 77 cases of NHL.
Results:
In NHL, the positive rates of PTEN and p27 protein were 90.9% (70/77) and 51.9% (40/77), respectively. The positive strength of PTEN protein was positively correlated to that of p27 protein (r = 0.6841, P < 0.01). The expression intensity of PTEN and p27 proteins in the low grade group was all higher than that in the high grade group. The expression intensity of PTEN and p27 proteins in B NHL showed no significant difference with that of T NHL.
Conclusion:
The decrease of p27 protein expression caused by the deletion and descent of PTEN protein expression cannot effectively play the anti-oncogene role in negative regulation of the cell cycle, which makes the tumor cells more malignant.
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