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[AT1 receptor autoantibodies and essential hypertension]
Hong Liu1, Yu Yang, Long-long Chen
1Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Objective:
To observe the relationship between AT1 receptor autoantibodies and clinical features in essential hypertension, and to compare the therapeutic effect of losartan between the positive and the negative group.
Methods:
Clinical data were collected in patients with essential hypertension (n = 123). AT1 receptor autoantibodies were checked. Twenty-four patients from either AT1-positive or AT1-negative group were treated with losartan for 12 weeks.
Results:
The average age in the positive group was significantly higher than that of the negative one (P = 0.023). Logistic regression analysis indicated that age was an independant risk factor of AT1 receptor autoantibody. Antihypertensive efficiency of losartan showed no obvious difference between the two groups.
Conclusion:
Positive response of AT1 receptor autoantibody is related only to age. Anti-hypertensive therapy with losartan in the positive group shows no advantage over the negative one, indicating that AT1 receptor autoantibodies possibly have no vascular activity in vivo.