Related Experiment Video
Updated: Aug 29, 2026
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
Published on: September 18, 2013
[Inhibitive effect of soybean isoflavone on prostate hyperplasia in rats]
1Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha 410078, China.
Objective:
To explore the inhibitive effect of soybean isoflavone on benign prostatic hyperplasia in rats.
Methods:
By subcutaneously injecting testosterone propionate to induce prostate hyperplasia in rats, the changes of prostate wet weight, prostatic index, morphological change, prostate-specific acid phosphatase (PAP), acid phosphatase in the control, the model, low, moderate, high dose of soybean isoflavone groups were observed.
Results:
The ventral prostate wet weight, prostatic index, and PAP in the low, moderate, and high dose groups were significantly lower than those in the models (P < 0.05). The ventral prostate wet weight, prostatic index, and PAP in the moderate, and high dose groups were significantly lower than those in the low dose group (P < 0.05).
Conclusion:
Soybean isoflavone inhibits prostate hyperplasia and the increase of acid phosphatase and PAP in a dose-dependent manner in rats. Soybean isoflavone may serve as supplementary therapy and prevent benign prostatic hyperplasia.
