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Updated: Aug 29, 2026
Isolation of Cells with Morphological and Spatial Information from Oral Submucous Fibrosis Samples by Laser Capture Microdissection
Published on: August 11, 2023
[Expression of S100 in oral submucose fibrosis]
Xiao-li Xie1, Zhan-gui Tang, Zhi-gang Yao
1Department of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Objective:
To study the expression of S100 in oral submucose fibrosis(OSF).
Methods:
Immunohistochemistry assay was performed on 10 cases of OSF, 10 cases of oral epithelial dysplasia (OED) and 8 cases of normal oral epithelium using monoclonal antibody against S100 protein.
Results:
S100 did not express in the normal oral muscosal epithelium. The S100 positive nuclear staining was found in 50% of the OSF and OED cases, which was significantly higher than that in the normal oral epithelium (P < 0.05). But the positive staining in the OSF and OED cases had no difference (P > 0.05).
Conclusion:
S100 expression is closely related to the development of OSF and OED. The positive staining expression in the OSF and OED cases is the same.
