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[Non-radioactive in situ hybridization of alpha-satellite sequences in cytogenetic diagnosis]
C Perfumo1, A Arslanian, F Zara
1Centro Studi Regionale Sindrome di Down, Genova.
Pathologica
|May 1, 1992
Abstract:
Non isotopic in situ hybridization with alpha-satellite DNA probes in the cytogenetic diagnosis. Standard banding cytogenetic techniques do not always allow to define the structure and the origin of chromosome rearrangements involving the centromere region. Non-isotopic in situ hybridization of alphoid sequences has allowed to determine the origin of the centromeres in the metaphases of 5 patients referred to us for: 2 structural rearrangements involving chromosome 21, 2 structural rearrangements involving chromosome Y and 1 reciprocal translocation involving on chromosome 20 and one chromosome 15.