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[Efficacy of danazol in autoimmune hemolytic anemia with cold agglutinins. 4 cases]
The treatment of haemolytic anaemia related to primary cold agglutinin disease is often unsatisfactory. Corticosteroids are not useful in most cases and, beside protection against cold, treatment is frequently limited to transfusions. We report the good results obtained with long-term danazol therapy (600 mg per day initially, than 400 mg per day) in 3 cases of chronic cold agglutinin disease and 1 case of idiopathic haemolytic anaemia with cold agglutinin in serum. The only side-effect was a transient increase of transaminase level requiring reduction of a maintenance dose which could be given during 3 to 7 years.
The treatment of haemolytic anaemia related to primary cold agglutinin disease is often unsatisfactory. Corticosteroids are not useful in most cases and, beside protection against cold, treatment is frequently limited to transfusions. We report the good results obtained with long-term danazol therapy (600 mg per day initially, than 400 mg per day) in 3 cases of chronic cold agglutinin disease and 1 case of idiopathic haemolytic anaemia with cold agglutinin in serum. The only side-effect was a transient increase of transaminase level requiring reduction of a maintenance dose which could be given during 3 to 7 years.
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