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Updated: Aug 15, 2026

Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
Published on: August 22, 2018
Microwave-assisted [3 + 2] cycloadditions of azomethine ylides
George Bashiardes1, Imad Safir, Achmet Said Mohamed
1Département de Chimie, Méthodologie et Synthèse de Biomolécules, SFA-UMR 6514, Université de Poitiers, 40 avenue du Recteur Pineau, 86022 Poitiers, France. george.bashiardes@univ-poitiers.fr
Abstract:
The microwave-assisted intramolecular [3 + 2] cycloaddition reaction of azomethine ylides to activated and nonactivated alkenes and alkynes is described. The procedure allows the synthesis of pyrrolidines and pyrrole products in good to excellent overall yields in short reaction times. It appears from parallel comparative studies that the microwave procedure favors the reaction times and overall purity of the crude reaction mixture. The reactions can also be performed in the absence of solvent. [reaction: see text]
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