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Unchanged striatal dopamine transporter availability in narcolepsy: a PET study with [11C]-CFT
J O Rinne1, C Hublin, K Någren
1Turku PET-Centre, University of Turku, Turku, Finland. juha.rinne@pet.tyks.fi
Acta Neurologica Scandinavica
|December 5, 2003
Abstract
Objective:
To investigate dopamine reuptake sites (dopamine transporter) in the caudate nucleus and putamen in narcolepsy.
Patients And Methods:
Ten patients with narcolepsy and 15 controls were studied with positron emission tomography. A cocaine analogue [11C]-CFT was used as a radioligand.
Results:
The uptake of[11C]-CFT was within normal limits (89% of age-adjusted control mean in the caudate nucleus and 91% in the putamen) in patients with narcolepsy.
Conclusions:
No evidence of altered striataldopamine transporter availability was found in narcolepsy.