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Solvent effects on amphotericin B monolayers.

Jennifer Cannon Sykora1, William C Neely, Vitaly Vodyanoy

  • 1Department of Chemistry, Auburn University, Auburn, AL 36849, USA.

Journal of Colloid and Interface Science
|December 5, 2003
PubMed
Summary
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The antifungal amphotericin B forms distinct liquid states when spread from a specific solvent. This transition, however, fades over time, suggesting solvent retention or aggregate formation.

Area of Science:

  • Biochemistry
  • Materials Science

Background:

  • Amphotericin B is a vital antifungal agent.
  • Its behavior in thin films (monolayers) is crucial for understanding its properties.

Purpose of the Study:

  • To investigate the phase behavior of amphotericin B monolayers.
  • To determine the influence of solvent on monolayer transitions.

Main Methods:

  • Spreading amphotericin B from a chloroform/methanol solvent.
  • Observing liquid expanded/liquid condensed state transitions.

Main Results:

  • A distinct liquid expanded/liquid condensed state transition was observed.
  • This transition diminished with prolonged spreading times.
  • Potential causes include solvent retention or metastable aggregate formation.

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Conclusions:

  • The solvent plays a critical role in the initial monolayer phase behavior of amphotericin B.
  • Metastable aggregates or residual solvent may explain the transient nature of the observed transition.