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Tannic acid intoxication in sheep and mice
J Zhu1, L J Filippich, M T ALsalam
1Department of Companion Animal Medicine and Surgery, University of Queensland, Australia.
Research in Veterinary Science
|November 1, 1992
Summary
Tannic acid causes liver damage in mice and sheep when administered intraperitoneally. Oral tannic acid in sheep leads to metabolic acidosis and methaemoglobinaemia, but not significant liver injury.
Area of Science:
- Toxicology
- Veterinary Medicine
- Pharmacology
Background:
- Tannic acid is a plant-derived polyphenol with various industrial and medicinal uses.
- Understanding its toxicological profile is crucial for safety assessments.
Purpose of the Study:
- To investigate the acute toxicity of tannic acid in mice and sheep.
- To compare the effects of oral versus intraperitoneal administration in sheep.
Main Methods:
- Oral and intraperitoneal administration of tannic acid to mice and sheep.
- Histopathological examination of liver tissues.
- Biochemical analysis of plasma parameters.
- Blood gas and acid-base balance determination.
Main Results:
- Oral tannic acid induced liver necrosis in mice.
- In sheep, oral tannic acid caused focal hepatocellular necrosis and metabolic acidosis with methaemoglobinaemia.
- Intraperitoneal tannic acid in sheep resulted in liver necrosis and significant alterations in plasma biochemistry and blood gases.
Conclusions:
- Tannic acid exhibits hepatotoxicity in mice and sheep, depending on the route of administration.
- Oral administration in sheep leads to systemic effects like metabolic acidosis and methaemoglobinaemia rather than severe hepatic injury.
- The route of administration significantly influences the toxicological outcomes of tannic acid.