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Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
Published on: June 18, 2020
A quantitative analysis of the expression of alpha-smooth muscle actin in mesangioproliferative (GnMes)
Edyta Nieruchalska1, Rafał Strzelczyk, Aldona Woźniak
1Laboratory of Morphometry and Medical Image Processing, Chair of Pathology, University of Medical Sciences,Poznań, Poland.
Abstract:
The aim of the study was to quantitatively assess the expression of alpha-SMA in the renal interstitium in GnMes cases. Two image analysis approaches (in grey scale and in spatial colour images) were used to determine correctly the presence of the reaction. In spatial evaluation, the mean area fraction of a-SMA in the renal interstitium was 3.63% +/- 1.29%, while the results obtained from traditional quantitative method based on grey scale images were biased and too low.
