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Related Experiment Videos

Intestinal neuronal dysplasia.

Prem Puri1

  • 1Children's Research Centre, Our Lady's Hospital for Sick Children University College, Dublin, Ireland, UK.

Seminars in Pediatric Surgery
|December 5, 2003
PubMed
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This summary is machine-generated.

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Intestinal neuronal dysplasia (IND) is a rare condition mimicking Hirschsprung disease. Animal models with specific gene knockouts provide evidence supporting IND as a distinct entity, aiding diagnosis and management.

Area of Science:

  • Gastroenterology
  • Developmental Biology
  • Histopathology

Background:

  • Intestinal neuronal dysplasia (IND) presents clinically similar to Hirschsprung's disease.
  • The existence of IND as a distinct histopathologic entity has been debated.
  • Animal models are crucial for understanding complex human diseases.

Purpose of the Study:

  • To review the diagnostic criteria for Intestinal Neuronal Dysplasia (IND).
  • To discuss staining techniques relevant to IND diagnosis.
  • To correlate histological findings with clinical symptoms and management strategies for IND.

Main Methods:

  • Review of existing literature on Intestinal Neuronal Dysplasia (IND).
  • Analysis of data from HOX11L1 knockout mouse models.

Related Experiment Videos

  • Examination of findings from endothelin B receptor-deficient rat models.

    • Main Results:

    • HOX11L1 knockout mice and endothelin B receptor-deficient rats exhibit submucous plexus abnormalities.
    • These abnormalities in animal models mirror those observed in human IND.
    • This provides strong evidence for IND as a distinct pathological entity.

    Conclusions:

    • Animal models offer compelling evidence for the distinct nature of Intestinal Neuronal Dysplasia (IND).
    • Detailed understanding of diagnostic criteria, histology, and clinical correlation is essential.
    • This review synthesizes key information for the diagnosis and management of IND.