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[Drug-induced hyperprolactinemia and galactorrhea].

M Bozzolo¹, W E Haefeli, G Noll

¹Departement Innere Medizin, Universitätskliniken, Kantonsspital Basel.

Schweizerische Rundschau Fur Medizin Praxis = Revue Suisse De Medecine Praxis

|December 8, 1992

Summary

A young woman experienced hyperprolactinemia and galactorrhea after taking metoclopramide for gastric issues. Symptoms resolved upon drug discontinuation, highlighting potential differences in dopamine antagonist effects.

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Area of Science:

Endocrinology
Pharmacology

Background:

Dopamine antagonists like domperidone and metoclopramide are used for gastrointestinal disorders.
These drugs can potentially elevate prolactin levels, a condition known as hyperprolactinemia.

Observation:

A 21-year-old female developed significant hyperprolactinemia (3055 microU/l) with galactorrhea after a brief course of metoclopramide.
Symptoms rapidly resolved after metoclopramide withdrawal, with prolactin levels normalizing within two weeks.

Findings:

The patient had previously tolerated domperidone without similar side effects.
This case suggests potential differences in the central nervous system penetration or activity between metoclopramide and domperidone.

Implications:

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Highlights the importance of monitoring prolactin levels in patients using dopamine antagonists.

Suggests metoclopramide may have a higher propensity to induce hyperprolactinemia and galactorrhea compared to domperidone in susceptible individuals.