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Intramyocellular lipid, adiposity, and muscle oxygen supply in prepubertal type 1 diabetes

Andrew H Ling1, Kim C Donaghue, Neville J Howard

  • 1Human Nutrition Unit, University of Sydney, Children's Hospital at Westmead, Australia.

Pediatric Diabetes
|December 6, 2003
PubMed

Insights

Intramyocellular lipid (IMCL) accumulation in children with type 1 diabetes is not linked to glycemic control or diabetes duration. Improving muscle oxygen supply may help reduce adiposity in these children.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Research
  • Diabetes Complications

Background:

  • Intramyocellular lipid (IMCL) accumulation is linked to obesity and reduced muscle oxygen supply in non-diabetics.
  • IMCL levels are elevated in type 1 diabetes, but their clinical significance remains unclear.

Purpose of the Study:

  • To investigate the relationship between IMCL content, muscle oxygenation, adiposity, and glycemic control in prepubertal boys with type 1 diabetes.

Main Methods:

  • Studied 16 prepubertal boys with type 1 diabetes (age 6.4-9.9 yr).
  • Assessed adiposity via anthropometry.
  • Measured muscle oxygen supply using near-infrared spectroscopy (NIRS).
  • Quantified abdominal and IMCL content using magnetic resonance imaging (MRI) and spectroscopy (MRS).

Main Results:

  • IMCL content did not correlate with muscle reoxygenation rate, abdominal adiposity, diabetes duration, or glycemic control (HbA1c).
  • Muscle reoxygenation rate was associated with body fat percentage, visceral and subcutaneous abdominal fat volume, and dietary fat intake.
  • Hemoglobin A1c (HbA1c) showed a significant relationship only with dietary fat intake.

Conclusions:

  • Findings suggest IMCL accumulation in type 1 diabetes may not be directly tied to glycemic control or muscle oxygen supply in this cohort.
  • Interventions targeting improved muscle oxygenation could potentially mitigate adiposity development in children with type 1 diabetes.
Abstract

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