June 2003: 33-year-old male with a frontal lobe mass
1Department of Pathology and Laboratory Medicine (Neuropathology), Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, Calif, USA.
Abstract:
The June 2003 COM. A 33-year-old male with a history of seizures was found to have an intra- and extra-axial frontal lobe mass. The histology of the resected tumor showed a meningioma with underlying meningioangiomatosis. Meningioangiomatosis (MA) is a benign intracortical plaque-like proliferation of meningothelial cells, microvasculature and fibroblast-like cells probably of hamartomatous origin. Very rarely, MA is associated with an overlying meningioma as in this case. When MA is accompanied by a meningioma, it is generally not associated with clinical evidence of neurofibromatosis. It is important to distinguish MA from an invasive meningioma, because of its favorable prognosis after resection.
Insights
Meningioangiomatosis (MA) is a rare benign brain tumor. This case highlights MA associated with a meningioma, emphasizing its distinct diagnosis and favorable prognosis.
Area of Science:
- Neurology
- Neurosurgery
- Pathology
Background:
- Meningioangiomatosis (MA) is a rare, benign proliferation of meningothelial cells, microvasculature, and fibroblast-like cells, often of hamartomatous origin.
- It typically presents as an intracortical plaque-like lesion.
- MA is infrequently associated with overlying meningiomas.
Observation:
- A 33-year-old male with a history of seizures presented with an intra- and extra-axial frontal lobe mass.
- Histological examination of the resected tumor revealed a meningioma with underlying meningioangiomatosis.
- This specific co-occurrence of MA and meningioma is exceptionally rare.
Findings:
- The co-occurrence of meningioangiomatosis and meningioma in this patient did not present with clinical evidence of neurofibromatosis.
- Distinguishing MA from invasive meningioma is crucial due to their differing prognoses.
- The histological features confirmed a benign meningioma overlying a meningioangiomatosis lesion.
Implications:
- Accurate differentiation between meningioangiomatosis and invasive meningioma is critical for appropriate patient management.
- Recognition of this rare association aids in understanding the spectrum of meningioma-related pathologies.
- The favorable prognosis of meningioangiomatosis following resection underscores the importance of precise diagnosis.