Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperhomocysteinemia and immune activation.

Katharina Schroecksnadel1, Barbara Frick, Christiana Winkler

  • 1Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria.

Clinical Chemistry and Laboratory Medicine
|December 6, 2003
PubMed
Summary

Immune system activation may drive hyperhomocysteinemia, a risk factor for vascular diseases. This process can deplete essential vitamins like folate, even with adequate intake, suggesting a secondary role for vitamin deficiency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrauterine human chorionic gonadotropin administration before embryo transfer (IHABT): an individual participant data meta-analysis of randomized controlled trials.

Human reproduction update·2026
Same author

Dendritic cells under the control of the preimplantation embryo secretome: an in vitro study.

Reproductive biology and endocrinology : RB&E·2024
Same author

Embryo drop-out rates in preimplantation genetic testing for aneuploidy (PGT-A): a retrospective data analysis from the DoLoRes study.

Journal of assisted reproduction and genetics·2023
Same author

Comment on the recent PGDIS Position Statement on the Transfer of Mosaic Embryos 2021.

Journal of assisted reproduction and genetics·2022
Same author

Diagnosing chronic endometritis: when simplification fails to clarify.

Human reproduction open·2022
Same author

Medical research and reproductive medicine in an ethical context: a critical commentary on the paper dealing with uterine lavage published by Munné et al.

Journal of assisted reproduction and genetics·2020

Area of Science:

  • Biochemistry
  • Immunology
  • Vascular Biology

Background:

  • Hyperhomocysteinemia is a known risk factor for atherosclerosis and thrombosis.
  • The precise role of vitamin deficiency and homocysteine accumulation in disease pathogenesis remains unclear.
  • Hyperhomocysteinemia often co-occurs with immune system activation in various diseases.

Purpose of the Study:

  • To investigate the relationship between immune system activation and homocysteine metabolism.
  • To explore whether immune activation contributes to the development of hyperhomocysteinemia.
  • To understand the interplay between cellular immunity, vitamin levels, and homocysteine in disease.

Main Methods:

  • In vitro experiments with stimulated peripheral blood mononuclear cells.

Related Experiment Videos

  • Analysis of homocysteine, folate, vitamin B12, neopterin, and peroxide concentrations in patient cohorts (coronary heart disease, rheumatoid arthritis, dementia).
  • Correlation studies between immune activation markers and homocysteine/vitamin levels.

    • Main Results:

    • Homocysteine accumulates in stimulated immune cells.
    • Inverse correlation between homocysteine and folate levels.
    • Positive correlation between homocysteine and immune activation markers (e.g., neopterin).
    • In dementia patients, elevated serum peroxides, homocysteine, and neopterin correlate.
    • Evidence suggests immune activation contributes to hyperhomocysteinemia development.

    Conclusions:

    • Immune system activation plays a significant role in the development of hyperhomocysteinemia.
    • Immune cell stimulation can lead to oxidative stress, depleting antioxidants and B-vitamins.
    • This process can result in increased homocysteine and vitamin deficiency, irrespective of dietary intake.