Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet adhesion to simulated stented surfaces.

Samuel Robaina1, Bhavani Jayachandran, Yong He

  • 1Biomedical Engineering Institute, Florida International University, Miami, Florida, USA.

Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists
|December 6, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Future of Trauma Care in Aotearoa New Zealand: Towards a Collaborative Model.

Emergency medicine Australasia : EMA·2026
Same author

Projection targets of efferent neurons in the internal branch of the superior laryngeal nerve in rats: microdissection and glycogen depletion, immunhistochemical nerve fibre analysis, electromyographic study and three dimensional reconstruction.

Anatomical science international·2026
Same author

Excessive Shear Rate, Not Shear Stress, Influences Cell Mechanical Damage in Small-Bore Needle Injections.

Journal of biomechanical engineering·2026
Same author

Outcomes of major trauma patients by hospital level of care in New Zealand.

Injury·2026
Same author

pH-Corrected Ionised Calcium Predicts Coagulopathy After Major Trauma: A Retrospective Cohort Study.

Emergency medicine Australasia : EMA·2025
Same author

Atherosclerosis increases adventitial pressure and limits solute transport via fluid-balance mechanisms.

Biomechanics and modeling in mechanobiology·2025
Same journal

Conservative, Endovascular, and Open Repair Treatment for Proximal Bare Metal Stent-Strut Separation and Consecutive Dysfunction of the Suprarenal Fixation and Dislocation of the EVAR Stent-Graft Prosthesis.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2026
Same journal

Hybrid Management of Subclavian-Axillary Artery Aneurysms in Loeys-Dietz Syndrome After Prior Aortic Arch Repair: Technical Note.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2026
Same journal

Stent-Graft Placement for the Management of Iliac Artery Hemorrhage in Patients With Pelvic Malignancy: Clinical Outcomes and Patency.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2026
Same journal

Distal Puncture-Assisted Bidirectional Endovascular Therapy for Femoropopliteal Chronic Total Occlusion: Efficacy and CIRSE-Graded Complications (DIPLOMA Study).

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2026
Same journal

Modified Snare-Ride Technique for Target Vessel Stenting in FB-EVAR.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2026
Same journal

Long-Term Efficacy of Lutonix in a Real-World Femoropopliteal Patients With Peripheral Arterial Disease: Insights From the SAFE-DCB US Registry.

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists·2026
See all related articles

Smaller stent strut spacing reduces platelet adhesion, a key factor in stent restenosis. This finding highlights the importance of stent design in minimizing blood flow disruptions and improving patient outcomes.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Materials Science

Background:

  • Stent implantation can lead to intimal hyperplasia and restenosis.
  • Stent strut protrusion into the bloodstream can alter flow dynamics and cause stagnation.
  • Platelet adhesion is a critical early event in the thrombotic and restenotic processes following stent placement.

Purpose of the Study:

  • To investigate the impact of stent strut spacing on platelet adhesion.
  • To determine if flow stagnation caused by strut protrusion influences platelet deposition.
  • To correlate stent design parameters with biological responses.

Main Methods:

  • Utilized 2D stent models with varying strut spacings (2.5, 4.0, 7.0 times strut height) in a flow chamber.

Related Experiment Videos

  • Labeled human platelets with Indium-111 to quantify adhesion.
  • Simulated pulsatile blood flow (10+/-5 dynes/cm2 at 1 Hz) and measured radioactivity using a gamma counter.
  • Employed computational fluid dynamics to analyze flow separation and wall shear stress.

    • Main Results:

    • All tested stents increased platelet adhesion compared to bare surfaces (p<0.05).
    • Stents with wider strut spacing (4.0 and 7.0 models) exhibited significantly higher platelet adhesion on the substrate than those with smaller spacing (2.5 model).
    • Platelet adhesion directly on stent struts was 3-7 times higher than on the surrounding substrate, also dependent on strut spacing.

    Conclusions:

    • Stent design significantly influences blood flow patterns and subsequent platelet adhesion.
    • Minimizing platelet adhesion is crucial for reducing intimal hyperplasia and restenosis.
    • Smaller stent strut spacings appear to be superior in reducing platelet adhesion per unit strut area, suggesting a design strategy for improved stent performance.