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AMH signaling: from receptor to target gene
1Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands. j.visser@erasmusmc.nl
Molecular and Cellular Endocrinology
|December 6, 2003
Abstract:
Anti-Müllerian hormone (AMH), also known as Müllerian inhibiting substance (MIS), is a member of the transforming growth factor beta (TGFbeta) superfamily and plays a crucial role during male sexual differentiation. Although the AMH type II receptor has been identified, the identity of the other signaling components has remained unknown. This review describes the identification of candidate AMH type I receptors and an AMH-target gene involved in Müllerian duct regression.