Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Long stemmed total knee arthroplasty with interlocking screws: a computational bone adaptation study.

Jeffry S Nyman1, Scott J Hazelwood, Juan J Rodrigo

  • 1Biomedical Engineering Graduate Group, College of Engineering, University of California at Davis, Davis, CA 95616, USA. jsnyman@ucdavis.edu

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|December 6, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hypertension worsens bone loss and weakens bone in aged ovariectomized mice.

JBMR plus·2026
Same author

Programmed cell death ligand 1 (PD-L1) inhibition in tumor naïve mice is bone-sparing throughout the lifespan.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

A Probabilistic Three-Dimensional Finite Element Model of a Cemented Hip Implant Failure Under Aseptic Loosening: A Case-Based Probabilistic Framework.

Bioengineering (Basel, Switzerland)·2026
Same author

Sites of non-enzymatic crosslinks pentosidine and glucosepane in collagen I of human cortical bone.

Bone·2026
Same author

MEK inhibitor mirdametinib promotes fracture healing in osteofibrous dysplasia RASopathy.

The Journal of clinical investigation·2026
Same author

Attenuation of Transforming Growth Factor-β Signaling Promotes Complete Recovery of Trabecular Bone Structure Following Immobilization With Traumatic Spinal Cord Injury.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Interlocking screw fixation with bony ingrowth and cemented fixation minimize tibial bone loss after total knee arthroplasty (TKA). Other interlocking techniques did not reduce bone loss.

Area of Science:

  • Orthopedic surgery
  • Biomedical engineering
  • Bone remodeling

Background:

  • Stress shielding and subsequent bone loss are concerns following total knee arthroplasty (TKA).
  • The degree of bone ingrowth and stem-bone bonding may influence stress shielding.
  • Understanding bone remodeling dynamics is crucial for optimizing implant fixation.

Purpose of the Study:

  • To investigate the efficacy of interlocking screw fixation in minimizing tibial bone loss compared to cement and press-fit fixation.
  • To evaluate the impact of bony ingrowth and intimate stem-bone bonding on stress shielding.
  • To predict bone remodeling changes after TKA using a finite element model.

Main Methods:

  • A two-dimensional finite element model of the tibia was developed.

Related Experiment Videos

  • The model incorporated a damage- and disuse-based bone remodeling theory.
  • Four fixation techniques were simulated: cement, press-fit, interlocking with bony ingrowth, and interlocking without bony ingrowth.

    • Main Results:

    • All TKA fixation techniques predicted elevated bone remodeling and loss due to disuse.
    • Interlocking stems with full bony ingrowth and cemented stems resulted in the least tibial bone loss.
    • Interlocking stems with a smooth, matted finish did not mitigate bone loss.

    Conclusions:

    • Interlocking screw fixation with bony ingrowth and cemented fixation are effective in minimizing bone loss post-TKA.
    • Intimate bony ingrowth or rigid cement fixation can reduce stress shielding effects.
    • Further research into interlocking fixation designs is warranted to optimize bone preservation.