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Patterns and risk factors for systemic calcified atherosclerosis.

Matthew A Allison1, Michael H Criqui, C Michael Wright

  • 1University of California, San Diego, California, USA. mallison@ucsd.edu

Arteriosclerosis, Thrombosis, and Vascular Biology
|December 6, 2003
PubMed
Summary

Systemic atherosclerotic calcification patterns show strong correlations across vascular beds. Age and hypertension are key risk factors for calcified atherosclerosis, impacting men and women differently.

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Area of Science:

  • Cardiovascular Imaging
  • Atherosclerosis Research
  • Medical Diagnostics

Background:

  • Atherosclerotic lesions contain calcification, which correlates with disease severity.
  • Understanding systemic calcification patterns is crucial for assessing cardiovascular risk.

Purpose of the Study:

  • To investigate the patterns and correlations of systemic atherosclerotic calcification.
  • To identify dominant risk factors associated with calcified atherosclerosis across various vascular beds.

Main Methods:

  • Utilized whole-body electron beam computed tomography (CT) scans.
  • Assessed 650 asymptomatic subjects for calcification in carotid, coronary, aorta, and iliac vessels.
  • Analyzed correlation patterns and risk factors, including age and hypertension.

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Main Results:

  • Significant correlations observed between calcification in different vascular beds, particularly the distal aorta and iliac vessels (r=0.51 to 0.60).
  • Earliest calcification occurred in coronaries (men <50) and distal aorta (women 50-60).
  • Prevalence of calcification increased with age; all subjects over 70 had some calcification. Age and hypertension were primary risk factors.

Conclusions:

  • Confirmed significant correlations in calcified atherosclerosis across diverse vascular beds.
  • Established strong associations between systemic calcification and key risk factors like age and hypertension.