Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rofecoxib does not compromise platelet aggregation during anesthesia and surgery.

David G Silverman1, Thomas Halaszynski, Raymond Sinatra

  • 1Departments of Anesthesiology and Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticutt 06520-8051, USA. david.silverman@yale.edu

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|December 6, 2003
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Total Reversal of ALS Confirmed by EMG Normalization, Structural Reconstitution, and Neuromuscular-Molecular Restoration Achieved Through Computerized Brain-Guided Reengineering of the 1927 Nobel Prize Fever Therapy: A Case Report.

Diseases (Basel, Switzerland)·2025
Same author

Changing Incidence and Nature of Injuries Caused by Falls From Skateboards in the United States.

Clinical pediatrics·2019
Same author

Injuries Caused by Falls From Playground Equipment in the United States.

Clinical pediatrics·2017
Same author

Dexmedetomidine Added to Local Anesthetic Mixture of Lidocaine and Ropivacaine Enhances Onset and Prolongs Duration of a Popliteal Approach to Sciatic Nerve Blockade.

Clinical therapeutics·2016
Same author

Ventilation-Induced Modulation of Pulse Oximeter Waveforms: A Method for the Assessment of Early Changes in Intravascular Volume During Spinal Fusion Surgery in Pediatric Patients.

Anesthesia and analgesia·2016
Same author

Neuraxial and peripheral nerve blocks in patients taking anticoagulant or thromboprophylactic drugs: challenges and solutions.

Local and regional anesthesia·2015

Cyclooxygenase type 2 (COX)-2 inhibitors like rofecoxib do not impair platelet aggregation during anesthesia and surgery. This study confirms COX-2 inhibitors do not interfere with aspirin

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Hematology

Background:

  • Clinicians hesitate to use COX-2 inhibitors perioperatively due to concerns about platelet function.
  • Existing evidence on COX-2 inhibitors and platelet function primarily involves healthy volunteers.

Purpose of the Study:

  • To evaluate the effect of rofecoxib (ROF) on platelet aggregation during anesthesia and surgery.
  • To provide definitive evidence for the perioperative use of COX-2 inhibitors.

Main Methods:

  • A randomized, double-blinded study involving 20 patients undergoing lower abdominal/pelvic surgery.
  • Platelet aggregometry was performed at baseline and post-administration of rofecoxib or placebo, with challenges using ADP and arachidonic acid.
  • Aggregometry was also assessed with aspirin to evaluate interference with its antiplatelet effects.

Related Experiment Videos

Main Results:

  • Both rofecoxib and placebo groups showed similar intraoperative declines in platelet aggregation in response to ADP and arachidonic acid.
  • Aspirin's effect on platelet aggregation was consistent across both groups, indicating no interference from rofecoxib.
  • No significant differences in platelet aggregation were observed between the rofecoxib and placebo groups.

Conclusions:

  • Rofecoxib does not compromise platelet aggregation during anesthesia and surgery.
  • COX-2 inhibitors can be safely administered perioperatively without affecting platelet function or aspirin's inhibitory effects.