Impaired visual and odor recognition memory span in patients with hippocampal lesions
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Updated: Aug 29, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Published on: June 4, 2020
Daniel A Levy1, Joseph R Manns, Ramona O Hopkins
1Veterans Affairs Healthcare System, San Diego, California 92161, USA.
Abstract:
In a recent study, rats with hippocampal lesions performed as well as did unoperated rats on an olfactory memory span task, performing approximately 80% correct even when the span length reached 24 odors. This finding seems potentially at odds with demonstrations that memory-impaired patients typically fail tasks in which large amounts of information must be retained. Accordingly, we have assessed recognition memory span performance for line drawings of objects, designs, and odors in amnesic patients with damage thought to be limited to the hippocampal region. The patients were impaired on all three tasks. We consider possible explanations for the difference between the findings for humans and rats, including the fact that olfactory function is particularly well-developed in rodents.
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