Adrenal androgens in patients with chronic marked elevation of prolactin

It has been postulated, based on data in animals and the fact that the cortisol-adrenal androgen ratio is different before and after adrenarche, that prolactin (Prl) may modulate adrenal androgen secretion. As one way of testing this hypothesis, cortisol, androstenedione (A), dehydroepiandrosterone (DHA), and dehydroepiandrosterone sulphate (DHAS) were measured by radioimmunoassay in the sera of thirteen patients with suspected or proven pituitary tumours and marked chronic elevations of serum Prl (range 68-990 ng/ml, mean 198.9 ng/ml). Values for cortisol, A, DHA, and DHAS were not significantly different between the groups of normal controls and patients with elevated Prl concentrations. This is interpreted as negative evidence for the theoretical connection between Prl and adrenal androgen secretion.