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Published on: July 21, 2015
Miniature transmitter release: accident of nature or careful design?
1Kinsmen Laboratory and Brain Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3.
Abstract:
Miniature transmitter release results from the constitutive low-level release of individual vesicles of neurotransmitter. Since the 1950s, this form of synaptic transmission has largely been thought to reflect a leaky evoked-release mechanism, and it was not clear whether it had a function of its own. Recent data challenge this view and suggest that miniature release can affect both the local chemistry of synapses and the network properties of neurons.
