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Drosophila invasive tumors: a model for understanding metastasis
Elisa C Woodhouse1, Lance A Liotta
1National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. elisa@mail.nih.gov
Cell Cycle (Georgetown, Tex.)
|December 6, 2003
Abstract:
Inactivation of Drosophila tumor suppressor genes can cause excessive proliferation and, in some cases, neoplastic growth. Neoplastic growth in Drosophila tissues can also be followed by metastasis upon transplantation into hosts or in vivo. Recently, we have shown that metastatic tumors of Drosophila can provide a model in which to identify genes that are involved in the metastatic process.