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Related Experiment Videos

Peripheral T-cell lymphomas expressing CD30 and CD15.

Todd S Barry1, Elaine S Jaffe, Lynn Sorbara

  • 1Hematopathology Section, Laboratory of Pathology, National Cancer Intitute, National Institutes of Health, Bethesda, MD 20892, USA.

The American Journal of Surgical Pathology
|December 6, 2003
PubMed
Summary

This study identifies rare cases of peripheral T-cell lymphomas (PTCLs) that express both CD30 and CD15, markers typically seen in Hodgkin

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Classic Hodgkin's lymphoma (HL) is characterized by CD30 and CD15 coexpression.
  • Peripheral T-cell lymphomas (PTCLs) can mimic HL histologically.
  • Coexpression of CD30 and CD15 in PTCL is infrequently reported.

Purpose of the Study:

  • To describe cases of PTCL with coexpression of CD30 and CD15.
  • To characterize the morphologic and immunophenotypic features of these PTCLs.
  • To differentiate these PTCLs from classic HL.

Main Methods:

  • Case series analysis of 11 PTCL patients.
  • Morphologic and immunophenotypic evaluation including CD30, CD15, CD20, CD79a, CD45, CD25, and T-cell markers.
  • Polymerase Chain Reaction (PCR) for T-cell receptor gamma (TCR-gamma) and immunoglobulin heavy (IgH) chain gene rearrangements.

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  • In situ hybridization for Epstein-Barr virus (EBV).

    • Main Results:

    • Eleven PTCL cases showed CD30 and CD15 coexpression in a subset of neoplastic cells.
    • Two groups were identified: 5 mimicking classic HL and 6 with PTCL morphology.
    • Molecular studies confirmed T-cell clonality (9/11 cases) and excluded B-cell origin.
    • EBV was negative in all cases.

    Conclusions:

    • PTCLs can exhibit CD30 and CD15 coexpression, mimicking classic HL.
    • Combined immunophenotypic and molecular analyses are crucial for accurate diagnosis.
    • These findings expand the spectrum of PTCL presentations.