[Comparative assessment of the WHO and Gilson histological classifications of prostatic neoplasms (taking into...

We estimated ploidometric nuclear parameters of predominating cell population in various prostatic adenocarcinomas in using WHO vs Glison classification to define advantages of the above classifications. Ploidometry provides information on cell composition and proliferative activity of cells. We observed greater ploidity in different grades of cell atypia. WHO histological classification by differentiation grade corresponds to ploidometric characterization of tumor cell populations but fails to reflect the presence of different histological types of the tumor. Currently introduced classification by Glison is more effective both diagnostically and prognostically as it reveals a dominant histological type of the tumor and shows other variants of tumor growth progression.