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[Caspase-3 inhibition blocks long-term potentiation in hippocampal slices]

I E Kudriashov1, A A Iakovlev, I V Kudriashova

  • 1Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow.

Zhurnal Vysshei Nervnoi Deiatelnosti Imeni I P Pavlova
|December 9, 2003
PubMed

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Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.