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Related Experiment Videos

Rhinitis/Bronchopneumonia syndrome in Irish Wolfhounds.

C Clercx1, I Reichler, D Peeters

  • 1Department of Small Animal Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Belgium. cclercx@stat.fmv.ulg.ac.be

Journal of Veterinary Internal Medicine
|December 9, 2003
PubMed
Summary

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Irish Wolfhounds may have a heritable rhinitis/bronchopneumonia syndrome. Affected dogs show respiratory signs, with some having abnormal IgA levels and neutrophil function, but no primary ciliary defects were found.

Area of Science:

  • Veterinary Medicine
  • Immunology
  • Genetics

Background:

  • Rhinitis and bronchopneumonia syndrome affects Irish Wolfhounds.
  • Clinical signs include rhinorrhea, cough, and dyspnea.

Purpose of the Study:

  • To investigate the clinical, immunologic, genetic, and pathologic features of this syndrome in Irish Wolfhounds.
  • To identify potential causes and heritable factors.

Main Methods:

  • Clinical examination, radiography, rhinoscopy, bronchoscopy.
  • Ciliary ultrastructure analysis.
  • Serum and bronchoalveolar lavage fluid (BALF) immunoglobulin (IgA, IgG, IgM) quantification.
  • Lymphocyte subset ratio (CD4:CD8) analysis.
  • Neutrophil phagocytosis assay.

Related Experiment Videos

  • Pedigree analysis.

    • Main Results:

    • No primary ciliary defects were detected.
    • Abnormal serum and BALF IgA concentrations were observed in affected dogs.
    • BALF CD4:CD8 ratio was elevated in one affected dog.
    • Decreased neutrophil phagocytosis was noted in one dog.
    • Pedigree analysis suggested a heritable basis for the syndrome.

    Conclusions:

    • The rhinitis/bronchopneumonia syndrome in Irish Wolfhounds appears to have a heritable component.
    • Immunologic abnormalities, including altered IgA levels and neutrophil function, may play a role.
    • Further investigation into the genetic and immunologic basis is warranted.