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The peptaibol database: a sequence and structure resource.

L Whitmore1, J K Chugh, C F Snook

  • 1Department of Crystallography, Birkbeck College, University of London, London WC1E 7HX, UK.

Journal of Peptide Science : an Official Publication of the European Peptide Society
|December 9, 2003
PubMed
Summary
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A new online database provides access to over 300 peptaibol sequences and structures. This resource aids researchers in studying these membrane-active peptides and their potential roles in ion channels.

Area of Science:

  • Biochemistry
  • Structural Biology
  • Bioinformatics

Background:

  • Peptaibols are a diverse family of membrane-active peptides with similar sequences but varying structures and functions.
  • Naturally occurring peptaibol variations offer valuable insights into ion channel structure-function relationships.

Purpose of the Study:

  • To introduce a comprehensive, searchable online database for peptaibol sequences and structures.
  • To facilitate research in structural biology and peptide science by consolidating peptaibol information.

Main Methods:

  • Development of a web-based platform (http://www.cryst.bbk.ac.uk/peptaibol) for data storage and retrieval.
  • Inclusion of sequence data, biological sources, literature references, and 3D structural coordinates (X-ray and NMR).
  • Implementation of search functionalities for specific sequences, motifs, and structural comparisons.

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Main Results:

  • The database currently houses over 300 peptaibol sequences and associated structural data.
  • Integrated molecular graphics illustrate model channel structures and comparative analyses.
  • Provides tools for detailed sequence and structure investigations of peptaibols.

Conclusions:

  • The peptaibol database serves as a crucial resource for the scientific community.
  • Enhances accessibility to vital information for structure-function studies of membrane-active peptides.
  • Supports ongoing research into the diverse biological roles of peptaibols.