Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Role of executive function in ADHD.

James M Swanson1

  • 1Department of Pediatrics, University of California, Irvine, CA 92612, USA. jmswanso@uci.edu

The Journal of Clinical Psychiatry
|December 9, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Fetal Exposure to Maternal Infection by SARS-CoV-2 and Effects on Child Neurodevelopment.

Journal of the American Academy of Child and Adolescent Psychiatry·2026
Same author

Reduced Efficacy of Behavior Therapy Following Initial Multimodal Treatment of ADHD.

Evidence-based practice in child and adolescent mental health·2025
Same author

Characteristics and Predictors of Fluctuating Attention-Deficit/Hyperactivity Disorder in the Multimodal Treatment of ADHD (MTA) Study.

The Journal of clinical psychiatry·2024
Same author

Placebo-related improvement with methylphenidate treatment in children with ADHD.

European child & adolescent psychiatry·2024
Same author

Psychometric properties of the self-report version of the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior Scale in a sample of Hungarian adolescents and young adults.

Frontiers in psychiatry·2024
Same author

Attention-deficit/hyperactivity disorder and dopamine receptor D4 (DRD4) exon 3 variable number of tandem repeats (VNTR) 2-repeat allele.

Annals of human genetics·2024
Same journal

Major Depressive Disorder and PTSD Treatment Outcome in Interpersonal Psychotherapy and Prolonged Exposure.

The Journal of clinical psychiatry·2026
Same journal

Psychiatrists and Medical Aid in Dying: Entering Uncharted Waters.

The Journal of clinical psychiatry·2026
Same journal

Mind and Metabolism in Crisis: US Mortality Involving Obesity and Psychiatric Disorders-Trends, Disparities, and ARIMA Projections.

The Journal of clinical psychiatry·2026
Same journal

Generative AI for the Clinical Psychopharmacologist: Is It Ready for Prime Time?

The Journal of clinical psychiatry·2026
Same journal

Posttrauma Benzodiazepine Use and Subsequent PTSD: A Population-Wide Analysis Following Extreme Traumatic Exposure.

The Journal of clinical psychiatry·2026
Same journal

The Challenges of PTSD Prevention: Placing Benzodiazepine Use in Context.

The Journal of clinical psychiatry·2026
See all related articles

Modafinil, a nonstimulant, may help manage attention-deficit/hyperactivity disorder (ADHD) symptoms by improving attention and executive functions. Further research is needed to confirm its effectiveness in children and adults.

Area of Science:

  • Neuropsychiatry
  • Pharmacology

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder impacting attention, hyperactivity, and impulsivity.
  • Current treatments include behavioral therapy and psychostimulants (methylphenidate, dextroamphetamine) targeting dopaminergic and noradrenergic systems.

Purpose of the Study:

  • To explore the potential efficacy of modafinil, a nonstimulant, in managing ADHD symptoms.
  • To investigate modafinil's proposed mechanisms of action, including effects on executive functioning and attention.

Main Methods:

  • The study reviews theoretical underpinnings and existing knowledge on modafinil's effects.
  • It discusses the need for placebo-controlled, flexible-dose studies.

Main Results:

Related Experiment Videos

  • Modafinil may improve attention and executive functions potentially related to ADHD symptoms.
  • Its primary mechanism may involve hypothalamic neuronal activity and hypocretin/orexin peptides, with a minor dopaminergic effect.

Conclusions:

  • Modafinil shows theoretical promise as an ADHD treatment by addressing attention and executive function deficits.
  • Further rigorous clinical trials are essential to establish modafinil's efficacy and safety for ADHD in various age groups.