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Does physical training increase insulin sensitivity in chronic heart failure patients?
L W E Sabelis1, P J Senden, B C M Te Boekhorst
1Department of Sports Medicine, University Medical Centre, Utrecht, The Netherlands. L.W.E.Sabelis@med.uu.nl
Clinical Science (London, England : 1979)
|December 9, 2003
Summary
Physical training improved peak oxygen uptake in chronic heart failure patients but did not significantly alter insulin sensitivity. The relationship between changes in insulin sensitivity and peak oxygen uptake warrants further investigation in this population.
Area of Science:
- Cardiology
- Exercise Physiology
- Metabolic Health
Background:
- Chronic heart failure (CHF) often involves impaired insulin sensitivity and reduced exercise capacity.
- The potential benefits of physical training on metabolic function in CHF patients require further clarification.
Purpose of the Study:
- To investigate the impact of a combined strength and endurance training program on insulin sensitivity (IS) in CHF patients.
- To examine the relationship between changes in IS and peak oxygen uptake (peak V(.)O(2)) following the intervention.
Main Methods:
- Seventy-seven CHF patients (NYHA class II/III) were randomized into a training group (TrG) or a control group (CG).
- The training program involved combined exercises four times weekly for the TrG.
- Insulin sensitivity was assessed using the euglycaemic hyperinsulinaemic clamp, and peak V(.)O(2) was measured via incremental cycle ergometry before and after the intervention.
Main Results:
- The intervention did not significantly alter IS in either group, although a trend towards increase was observed.
- Peak V(.)O(2) significantly increased in the TrG (6%) compared to a decrease in the CG (2%).
- A positive correlation was found between the changes in IS and peak V(.)O(2) in both groups.
Conclusions:
- Combined physical training in CHF patients enhances peak oxygen uptake but does not significantly improve insulin sensitivity.
- The unclear effect of physical training on insulin sensitivity in CHF patients necessitates further research.