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Related Experiment Videos

Performance of different mouse strains in an object recognition task.

Ayhan Sik1, Petra van Nieuwehuyzen, Jos Prickaerts

  • 1Department of Psychiatry and Neuropsychology, Brain and Behaviour Institute, Maastricht University, 6200 MD Maastricht, The Netherlands.

Behavioural Brain Research
|December 9, 2003
PubMed
Summary

Mice demonstrate object recognition memory, but performance declines with longer delays (24h) due to forgetting. This memory task shows minimal strain differences in mice.

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Area of Science:

  • Neuroscience
  • Animal Behavior

Background:

  • Object recognition is a fundamental cognitive ability.
  • Assessing memory in rodent models is crucial for understanding cognitive processes.

Purpose of the Study:

  • To evaluate memory performance in different mouse strains using an object recognition task.
  • To investigate the effect of delay intervals on object memory recall.
  • To determine if object recognition memory is strain-dependent in mice.

Main Methods:

  • Utilized a one-trial object recognition task with varying delay intervals (1h, 4h, 24h).
  • Tested four mouse strains: 129/Sv, BALB/c, C57BL, and Swiss.
  • Measured discrimination index (d2) to quantify memory performance.

Main Results:

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  • Mice exhibited good object memory with a 1-hour delay.
  • Memory performance significantly decreased with a 24-hour delay, indicating forgetting.
  • A 4-hour delay resulted in intermediate discrimination performance.
  • No significant strain differences were observed in the discrimination index (d2), despite variations in exploration activity.

Conclusions:

  • Object recognition memory can be reliably assessed in mice.
  • Forgetting is delay-dependent in this task.
  • Object recognition memory in mice appears to be relatively independent of genetic strain, unlike other memory paradigms.