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Contrast sensitivity improves after brimonidine therapy in primary open angle glaucoma: a case for neuroprotection
D W Evans1, S L Hosking, D Gherghel
1School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.
Aims:
To determine the visual outcome following initiation of brimonidine therapy in glaucoma.
Methods:
16 newly diagnosed previously untreated glaucoma patients were randomly assigned to either timolol 0.5% or brimonidine 0.2%. Visual acuity, contrast sensitivity (CS), visual fields, intraocular pressure (IOP), blood pressure, and heart rate were evaluated at baseline and after 3 months.
Results:
IOP reduction was similar for both groups (p<0.05). Brimonidine improved CS; in the right eye at 6 and 12 cpd (p=0.043, p=0.017); in the left eye at 3 and 12 cpd (p=0.044, p=0.046). Timolol reduced CS at 18 cpd in the right eye (p=0.041). There was no change in any other measured parameters.
Conclusion:
Glaucoma patients exhibit improved CS on initiation of brimonidine therapy.