Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oxygen sensing: applications in humans.

Neil S Cherniack1

  • 1New Jersey Medical School, The University of Medicine and Dentistry of New Jersey, Newark, NJ 07301, USA. cherniac@umdnj.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|December 9, 2003
PubMed
Summary

Oxygen sensing is a widespread tissue property, not limited to chemoreceptors, with dynamic responses to oxygen levels. This understanding aids in developing therapies for diseases like cancer.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exercise and sleep deprivation do not change cytokine expression levels in patients with chronic fatigue syndrome.

Clinical and vaccine immunology : CVI·2013
Same author

Historical perspectives on the control of breathing.

Comprehensive Physiology·2013
Same author

Respiratory and Cardiovascular Response during Electronic Control Device Exposure in Law Enforcement Trainees.

Frontiers in physiology·2013
Same author

Obstructive sleep apnea, metabolic syndrome, and age: will geriatricians be caught asleep on the job?

Aging clinical and experimental research·2010
Same author

Paradoxical potentiation of exercise hyperpnea in congestive heart failure contradicts Sherrington chemoreflex model and supports a respiratory optimization model.

Advances in experimental medicine and biology·2010
Same author

Cytokines across the night in chronic fatigue syndrome with and without fibromyalgia.

Clinical and vaccine immunology : CVI·2010

Area of Science:

  • Physiology
  • Cellular Biology
  • Respiratory Medicine

Background:

  • Oxygen sensing is a fundamental physiological process.
  • Historically, oxygen sensing was attributed solely to specialized chemoreceptors.
  • Recent research reveals oxygen sensing is a common property across various tissues.

Purpose of the Study:

  • To provide an updated perspective on oxygen sensing mechanisms.
  • To highlight the dynamic nature of physiological responses to oxygen fluctuations.
  • To explore the therapeutic potential of targeting hypoxia- and hyperoxia-induced pathways.

Main Methods:

  • Review of current literature on oxygen sensing.
  • Analysis of cellular and molecular pathways involved in oxygen response.
  • Examination of respiratory control mechanisms and their modulation.

Main Results:

  • Oxygen sensing is a ubiquitous tissue function, not confined to chemoreceptors.
  • Responses to oxygen levels are dynamic and change over time.
  • Hypoxia and hyperoxia trigger cellular pathways with therapeutic implications for diseases like cancer.
  • Human respiratory responses to hypoxia are complex, with limitations in measurement and modulation.

Conclusions:

  • Oxygen sensing is a complex, widespread physiological process.
  • Understanding oxygen sensing pathways opens avenues for novel therapeutic strategies.
  • Further research is needed to improve the measurement and manipulation of human ventilatory responses to oxygen deficiency.

Related Experiment Videos