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Related Experiment Videos

Effect of strong directional selection on weakly selected mutations at linked sites: implication for synonymous codon

Yuseob Kim1

  • 1Department of Biological Statistics and Computational Biology, Cornell University, New York, USA. ykim@mail.rochester.edu

Molecular Biology and Evolution
|December 9, 2003
PubMed
Summary

Strong directional selection can hinder the fixation of weakly selected mutations. This study shows that hitchhiking effects can explain the observed negative correlation between codon bias and nonsynonymous substitution rates in Drosophila.

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Area of Science:

  • Evolutionary genetics
  • Population genetics
  • Molecular evolution

Background:

  • Weakly selected mutations are influenced by selection at linked loci.
  • Codon usage bias is affected by selection on synonymous sites linked to nonsynonymous sites.

Purpose of the Study:

  • Investigate a two-locus model with weak and strong selection.
  • Analyze the impact of strong directional selection on linked weak selection.
  • Explain the negative correlation between codon bias and nonsynonymous substitution rates in Drosophila.

Main Methods:

  • Developed a two-locus population genetics model.
  • Derived approximations for allele frequencies at equilibrium.
  • Utilized simulation results for validation.

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  • Applied model to Drosophila data.

    • Main Results:

    • Codon bias decreases with increased substitution rates at the strongly selected locus.
    • Selection at one locus reduces selection efficacy at linked loci (hitchhiking effect).
    • The hitchhiking effect reasonably explains observed Drosophila data.

    Conclusions:

    • Strong directional selection significantly impacts fixation of linked mutations.
    • The hitchhiking model provides a plausible explanation for codon bias patterns in Drosophila.
    • A substantial proportion of nonsynonymous substitutions may be driven by strong selection.