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Quorum sensing in Staphylococcus infections.

Jeremy M Yarwood1, Patrick M Schlievert

  • 1Department of Microbiology, University of Iowa Roy J. and Lucille A. Carver College of Medicine, 540 Eckstein Medical Research Building, 500 Newton Road, Iowa City, Iowa 52242, USA. jeremy-yarwood@uiowa.edu

The Journal of Clinical Investigation
|December 9, 2003
PubMed
Summary
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The accessory gene regulator (agr) system in staphylococci, especially Staphylococcus aureus, is key to pathogenesis. Its regulation is complex in vivo, influenced by environment and other regulators, impacting biofilm infections.

Area of Science:

  • Microbiology
  • Molecular Biology
  • Pathogenesis

Background:

  • The accessory gene regulator (agr) system is crucial for staphylococcal pathogenesis, particularly in Staphylococcus aureus.
  • While agr's control of virulence genes is understood in vitro, its in vivo regulation and the quorum response are more complex.
  • Environmental factors and additional regulators significantly influence the agr system's activity.

Purpose of the Study:

  • To explore the complex regulation of the accessory gene regulator (agr) system in staphylococci, focusing on Staphylococcus aureus.
  • To investigate the role of the agr system in the pathogenesis of biofilm-associated infections.
  • To understand how environmental factors and additional regulators modulate the quorum response in vivo.

Main Methods:

Related Experiment Videos

  • Literature review on quorum sensing and agr system regulation in staphylococci.
  • Analysis of existing data on virulence gene expression in vitro and in vivo.
  • Examination of evidence linking agr phenotype to biofilm formation and chronic infections.

    • Main Results:

    • Agr system regulation is highly context-dependent, influenced by environmental signals beyond cell density.
    • The agr system's complexity in vivo necessitates considering multiple regulatory inputs.
    • Evidence suggests the agr phenotype impacts the behavior of biofilm-associated Staphylococcus aureus and Staphylococcus epidermidis.

    Conclusions:

    • The accessory gene regulator (agr) system's role in staphylococcal pathogenesis is intricate and environment-dependent.
    • Agr influences the behavior of bacteria in biofilms, potentially contributing to chronic infections.
    • Further research is needed to fully elucidate the in vivo regulation of agr and its impact on host-pathogen interactions.