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Updated: Aug 29, 2026
A Mouse Distraction Osteogenesis Model
Published on: November 14, 2018
[Expression of vascular endothelial growth factor during mandibular distraction osteogenesis in rabbits]
Jie Tang1, Jing Hu, Zhi-guo Wang
1Huaxi School of Stomatology, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the expression pattern of vascular endothelial growth factor (VEGF) in the distracted callus during mandibular osteodistraction.
Methods:
Bilateral mandibular osteotomies were performed in 12 rabbits. 3 rabbits were sacrificed respectively at 0, 7, 14 and 28 days after completion of distraction. The newly formed calluses were harvested and processed for histology and immunohistochemistry of VEGF.
Results:
Intense angiogenesis was observed in the regenerated callus after mandibular lengthening, and positive staining for VEGF was mainly noted in vascular endothelial cells and the active osteoblasts.
Conclusions:
Mechanical strain created by distraction led to angiogenesis in distraction gap. VEGF may play a critical role in angiogenesis and subsequent osteogenesis during mandibular lengthening.
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